| Matches | Home | Away | Goals | |||||||||||
| | PTS | GP | W | D | L | W | D | L | W | D | L | GS | GA | |
| 1 | APOEL Nicosia | 4 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3 | 2 |
| 2 | Zenit | 3 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 4 | 3 |
| 3 | Porto | 3 | 2 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 3 | 4 |
| 4 | Shakhtar Donetsk | 1 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3 |
| Tuesday September 13 | ||||
| 20:45 | FC Porto | 2 - 1 | Shakhtar Donetsk | Estádio do Dragão, Porto |
| 20:45 | APOEL Nicosia | 2 - 1 | Zenit St. Petersburg | GSP-Stadion, Nicosia |
| Wednesday September 28 | ||||
| 18:00 | Zenit St. Petersburg | 3 - 1 | FC Porto | Petrovskiy, St. Petersburg |
| 20:45 | Shakhtar Donetsk | 1 - 1 | APOEL Nicosia | Donbass Arena, Donetsk |
| Wednesday October 19 | ||||
| 20:45 | Shakhtar Donetsk | v | Zenit St. Petersburg | Donbass Arena, Donetsk |
| 20:45 | FC Porto | v | APOEL Nicosia | Estádio do Dragão, Porto |
| Tuesday November 1 | ||||
| 17:00 | Zenit St. Petersburg | v | Shakhtar Donetsk | Petrovskiy, St. Petersburg |
| 20:45 | APOEL Nicosia | v | FC Porto | GSP-Stadion, Nicosia |
| Wednesday November 23 | ||||
| 17:00 | Zenit St. Petersburg | v | APOEL Nicosia | Petrovskiy, St. Petersburg |
| 20:45 | Shakhtar Donetsk | v | FC Porto | Donbass Arena, Donetsk |
| Tuesday December 6 | ||||
| 20:45 | FC Porto | v | Zenit St. Petersburg | Estádio do Dragão, Porto |
| 20:45 | APOEL Nicosia | v | Shakhtar Donetsk | GSP-Stadion, Nicosia |
